The Sisters of St Anne's Ceduna convent will be blessed and opened next week.
The congregation dates back to the 19th century in India, founded by Thatipathri Gnanamma, and has a presence across the world with more than 650 members.
There are foundations in India, Germany, Italy, Spain, and in the South Australian towns of Ceduna and Port Augusta.
St Anne Sisters Nancy Ulahannan and Elizabeth Royan have been active in the Ceduna community for a number of months as part of the Centacare team and through their ministry.
Bishop of the Diocese of Port Pirie Gregory O'Kelly will be present, alongside sisters from India.
The community is welcome to attend the mass, which precedes the blessing and opening at Our Lady Star of the Sea Catholic Church at 10am next Wednesday.
Sister Ulahannan said their Ceduna ministry involved engaging with people on the periphery, listening to their stories and empowering them to be actively engaged in the community.
"Sister Elizabeth and I are enjoying the experience of being amongst friendly and warm-hearted people in Ceduna," she said.
The congregation was founded out of the pressing desire to empower women through education and has similarities in that respect to the work of Saint Mary of the Cross MacKillop, who brought the gift of education to the young in rural and remote parts of South Australia.